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AlzRisk Paper Detail

Reference: Fitzpatrick, 2009
Cohort: Cardiovascular Health Cognition Study/Cardiovascular Health Study Cognition Study
Risk Factor: Obesity

Exposure Detail
The authors evaluated associations between midlife BMI (self-reported BMI at age 50) and AD as well as late-life BMI (collected at baseline) and AD. This row of results corresponds to the association between midlife BMI and AD.

We have only provided results of the analyses adjusting for age, race, sex and educational level in these tables, and not those adjusting for potential intermediates such as DM.

Method of ascertaining BMI at age 50: self-report

"Anthropometric measurements in late life were collected in person at the clinic visit occurring closest to the time of the CHS MRI. These measurements included height, weight and waist-hip circumference in 1992-1993 (baseline for the CHS-Cognition). Midlife weight, however, relied on self-report of weight at age 50 years collected on the medical history form. Midlife BMI was calculated as weight in kilograms divided by height in meters squared and waist-hip ratio (WHR) as the ratio of waist to hip circumference."

Age Detail
Study entry criteria required participants to be at least 65 years of age.

Screening and Diagnosis Detail
Screening Method:
"Modified" 3MSE"Modified" Modified Mini-Mental State Examination (Tschantz 2002)
BVRTBenton Visual Retention Test (Benton 1974)
IQ-CODEInformant Questionnaire for Cognitive Decline in the Elderly (Jorm 1989)
TICSTelephone Interview of Cognitive Status
TMTTrail Making Test (Reitan 1958)

AD Diagnosis:
Brain Imaging
Medical History
NINCDS ADRDA National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer's Disease and Related Disorders Association Criteria (McKhann 1984)
Neuropsychological examination
WHO Stroke World Health Organization criteria for defining stroke (1993)

Covariates & Analysis Detail
Analysis Type:
Cox proportional hazards regression

AD Covariates:

TD Covariates: