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AlzRisk Paper Detail

Reference: Sattler, 2011
Cohort: German Interdisciplinary Longitudinal Study on Adult Development and Aging
Risk Factor: Physical Activity

Average Follow-up Time Detail
"Subjects have been followed up since 1993/94 for an average time of 12 years within three examination waves (t1: 1993/94; t2: 1997/98; t3: 2005/07)."

Exposure Detail
"Physical activity was assessed with a questionnaire at baseline. Participants were asked about their current and past sport activities using open-ended questions. Additionally, they were asked if they performed the respective activities on a regular basis and how many hours they spent on them per week. According to current WHO recommendations [31] subjects were classified as physically active if they reported at least one sport
activity, for at least once a week for two hours over any year-long interval. Subjects were classified as physically active throughout their whole lifetime if they fulfilled the above criteria during childhood (6–14 years), youth (14–20 years), young adulthood (20–40 years), mid-adulthood (40–60 years), and at t1. The remaining subjects were classified as 'never' or 'not continually physically active' according to their statements."

Ethnicity Detail
No data on ethnicity was reported, however all participants reside in Germany.

Age Detail
The 381 initially healthy participants from the 1930–32 birth cohort who completed the 3rd examination wave had an average age of 74 years.

Screening and Diagnosis Detail
Screening Method:
MMSEMini-Mental State Examination (Folstein 1975)
TMTTrail Making Test (Reitan 1958)

AD Diagnosis:
NINCDS ADRDA National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer's Disease and Related Disorders Association Criteria (McKhann 1984)

Vascular dementia diagnosis: NINDS-AIREN

Covariates & Analysis Detail
Analysis Type:
Logistic regression

Only participants with complete data on all variables were used.

AD Covariates:
BMIbody mass index
SESsocioeconomic status

Age was adjusted for through restriction, as participants comprised a birth cohort, born from 1930 through 1932, and were initially assessed from 1993 through 1994.

An additional model reported odds ratios for Always active vs. Not continually active as the reference, with similar results compared to Always active vs. Never active (OR: 1.24 [0.46-3.32]).