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AlzRisk Paper Detail

Reference: Morris, 2002
Cohort: Chicago Health and Aging Project
Risk Factor: Nutritional Antioxidants

Exposure Detail
Supplement use reported via food frequency questionnaire.

"Study participants completed a self-administered food frequency questionnaire …. The CHAP food frequency questionnaire, a modified version of the Harvard food frequency questionnaire, (31,32) was used to measure usual intake of 139 food items throughout the previous year, as well as the use of vitamin supplements. Nutrient intakes were computed by multiplying the nutrient contents of food items by frequency of consumption and summing across all items. Nutrient levels were adjusted for total energy intake separately for men and women by using the regression residual method. (33)"

Age Detail
Age at start of follow-up is the age at enrollment. Vitamin C intake assessed 1.7 years later, which was 2.3 years prior to dementia assessment.

Screening and Diagnosis Detail
AD Diagnosis:
NINCDS ADRDA National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer's Disease and Related Disorders Association Criteria (McKhann 1984)

Other diagnostic criterion: Although investigators used the NINCDS-ADRDA criteria as the basis for identifying AD cases, they also identified cases as "persons who met the criteria but had another coexisting condition that was thought to contribute to dementia."

“The 2 1⁄2-hour clinical evaluations were conducted in participants’ homes by a team consisting of a neurologist, nurse practitioner, and neuropsychological technician. The evaluations included a medical history, a structured neurological examination, neuropsychological testing (using the tests of Consortium Established for Research on Alzheimer’s Disease, CERAD34), informant interviews, and laboratory testing. Magnetic resonance imaging (MRI) was performed when dementia was evident and stroke occurrence was clinically uncertain (9 persons). A board-certified neurologist blinded to the dietary assessment data reviewed all clinical evaluation data before making clinical diagnoses of neurological diseases. Diagnoses of AD were made according to criteria of the National Institute of Neurological and Communicative Disorders and Stroke and Alzheimer’s Disease and Related Dementia Association (NINCDS ADRDA), 35 except that we did not exclude as cases persons who met the criteria but had another coexisting condition that was thought to contribute to dementia. Eleven persons with incident dementia caused by a condition other than AD were analyzed as noncases.”

Covariates & Analysis Detail
Analysis Type:
Logistic regression

Sample design accounted for use of weights in the analysis.

AD Covariates:
APOE4APOE e4 genotype
FUTfollow up time
SSstratified sampling
VITESsupplemental vitamin E
VITCDvitamin C dietary

Analysis included an interaction term between race and APOE e4.