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The HBO Alzheimer's Project
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AlzRisk Paper Detail
Non-Steroidal Anti-Inflammatory Drugs
Adult Health Study of the Radiation Effects Research Foundation
Average Follow-up Time Detail
Participants were originally recruited between 1965 and 1968. Screening for dementia occurred from 1992 to 1997.
Physical examinations completed between 1965 and 1968 provided information on midlife systolic blood pressure.
According to other
of the cohort, all participants were residents of Hiroshima or Nagasaki. Presumably, the vast majority are Japanese.
Participants were between the ages of 30 and 80 in 1965, with the majority of both men (80%) and women (75%) under age 50 and almost all participants under the age of 60 (97% of men and 96% of women).
Screening and Diagnosis Detail
Cognitive Abilities Screening Instrument (Teng 1994)
Diagnostic and Statistical Manual IV
"In health examinations between September 1992 and August 1997, 2,463 members of the AHS who provided informed consent (84.5% of the eligible AHS Hiroshima population born before September 1932) were screened for dementia using the Cognitive Ability Screening Instrument(CASI),
which consists of items identical or similar to those used in the Mini-Mental State Examination or Hasegawa’s Dementia Scale, widely used in epidemiological studies in Japan. A second examination was conducted for participants with low CASI score and participants selected randomly from among those with a high CASI score. The second examination included a neurological examination, completion of the Informative Questionnaire on Cognitive Decline in the Elderly by the caregiver, Hachinski’s Ischemic Score, and the Clinical Dementia Rating. Dementia and its subtypes were classified according to DSM-IV criteria."
Covariates & Analysis Detail