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AlzRisk Cohort Detail

Cohort: Indianapolis-Ibadan Dementia Project - Indianapolis Cohort
Risk Factors:

Introduction to the Cohort
The Indianapolis-Ibadan Dementia Project was established in 1991 to investigate the prevalence and incidence of dementia in African Americans and Yoruba ages 65+ and to compare rates across these populations. Baseline interviews were conducted in 1992-1993 and participants have been invited to participate in two waves of follow-up at two (1994-1995) and five years (1997-1998) after baseline.

Both community-based and institutionalized African American residents of Indianapolis, Indiana were were recruited to form the Indianapolis cohort. Community-based participants were recruited by use of door-to-door interviews conducted at addresses randomly sampled from census tracts that were >80% African American in the 1990 census. Institutionalized participants were recruited from six nursing homes in the Indianapolis area. 2,212 community-dwelling eligible persons and 106 institutionalized persons agreed to participate. 65% of all participants were female and the mean age of participants was 73.9.

Ethnicity Breakdown
All participants were African American.

Diagnosis & Evaluation Methods
A two-stage screening and diagnostic process was employed. For a detailed description of screening and diagnostic methods, please see Hendrie et al. (1995).

Hendrie HC, Ogunniyi A, Hall KS, Baiyewu O, Unverzagt FW, Gureje O, et al. Incidence of dementia and Alzheimer disease in 2 communities: Yoruba residing in Ibadan, Nigeria, and African Americans residing in Indianapolis, Indiana. JAMA. 2001 Feb 14;285(6):739-747.

Hendrie HC, Osuntokun BO, Hall KS, Ogunniyi AO, Hui SL, Unverzagt FW, et al. Prevalence of Alzheimer's disease and dementia in two communities: Nigerian Africans and African Americans. Am J Psychiatry. 1995 Oct;152(10):1485-1492.

Ogunniyi A, Hall KS, Gureje O, Baiyewu O, Gao S, Unverzagt FW, et al. Risk factors for incident Alzheimer's disease in African Americans and Yoruba. Metab Brain Dis. 2006 Sep;21(2-3):235-240.